食用添加劑網(wǎng)訊 2022年2月24日,據(jù)歐盟國(guó)家食品安全局(EFSA)信息,應(yīng)歐洲委員會(huì)規(guī)定,歐盟國(guó)家小動(dòng)物飼料添加物和商品(FEEDAP)科學(xué)研究工作組就大腸埃希菌DSM 32731生產(chǎn)制造的苞米赤霉烯酮核糖核苷酸(zearalenone hydrolase)做為全部陸生動(dòng)物飼料添加物的安全系數(shù)和實(shí)效性發(fā)布科學(xué)合理建議。
通過評(píng)定,權(quán)威專家工作組沒法就添加物對(duì)總體目標(biāo)外來物種、顧客、使用人和條件的安全系數(shù)作出結(jié)果。一部分全文報(bào)導(dǎo)如下所示:
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on zearalenone hydrolase (ZenA) produced by Escherichia coli DSM 32731 when used as a feed additive for all terrestrial animals. The production strain E. coli DSM 32731 is genetically modified and harbours a kanamycin resistance gene. No viable cells of the production strain were detected in the final product, but uncertainty remains on the presence of recombinant DNA in the final product. The ZenA contained in the additive is safe for all terrestrial animal species up to the maximum use levels of (in U/kg complete feed): 100 U/kg in chickens for fattening; 150 U/kg in laying hens, turkeys for fattening and rabbits; 200 U/kg in pigs; 250 U/kg in dairy cows; 400?U/kg in veal calf (milk replacer), cattle for fattening, sheep, goats, horses and cats; and 450 U/kg in dogs. based on the ADME and toxicological data, the FEEDAP Panel considers that the use of the ZenA contained in the additive in animal nutrition is safe for the consumers. The endotoxin content in the additive poses a risk by inhalation for users handling the additive. The additive is not a skin/eye irritant nor a skin sensitiser. Due to its proteinaceous nature, the additive should be considered as a potential respiratory sensitiser. The ZenA contained in the additive and the resulting breakdown products of its enzymatic activity do not represent a safety concern for the environment. The production strain harbours an antimicrobial resistance gene and uncertainties remain on the possible presence of its recombinant DNA in the final product; therefore, the FEEDAP Panel cannot conclude on safety of the additive for the target species, the consumer, the user and the environment.
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